Persistence and Adherence during the First Six Months of Tocilizumab Treatment Among Rheumatoid Arthritis Patients in Routine Clinical Practice in Greece. Results from the Single Arm REMISSION II Study (NCT01649817)
Identifieur interne : 000989 ( Main/Exploration ); précédent : 000988; suivant : 000990Persistence and Adherence during the First Six Months of Tocilizumab Treatment Among Rheumatoid Arthritis Patients in Routine Clinical Practice in Greece. Results from the Single Arm REMISSION II Study (NCT01649817)
Auteurs : Theodora E. Markatseli [Grèce] ; Athina Theodoridou [Grèce] ; Marina Zakalka ; Eftychia Koukli [Grèce] ; Eva Triantafyllidou [Grèce] ; Sotiris Tsalavos [Grèce] ; Alexandros Andrianakos [Grèce] ; Alexandros A. Drosos [Grèce]Source :
- Mediterranean Journal of Rheumatology [ 2529-198X ] ; 2019.
Abstract
One of the most important factors that affect a treatment’s performance in rheumatoid arthritis (RA) is adherence to medications. According to literature, there are several reasons for non-adherence in RA patients with some of them being related to a specific patient profile of the study population. In this study, we investigated persistence to intravenous tocilizumab (TCZ) therapy in RA during routine clinical practice in Greece and identified causes for non-adherence.
183 RA patients who mostly attended private practice Rheumatologists and received intravenous TCZ treatment at a schedule of 1 infusion per 4-weeks in the first 6 months were recorded retrospectively.
Persistence estimated rate to TCZ therapy was 92.0% for patients that received 6 infusions and 83.4% for patients that received 7 infusions of TCZ. Potential factors that influence persistence to therapy were the occurrence of adverse events and response to the therapy. The main reasons for non-adherence to TCZ therapy were non-medically related with the most common being drug supply issues. The 6-month mean change from baseline in DAS28-ESR after initiation of TCZ therapy was −1.3, and the mean CDAI dropped from 29.6 at baseline to 16.7 at 6 months. Good/Moderate response was achieved by 89.1% of patients and remission by 23.5%. The safety profile was similar to that observed in other TCZ trials with the most common being infections, hematologic manifestations and musculoskeletal disorders.
Overall, persistence to therapy appeared to be high in the rheumatology private practice setting and non-adherence to the TCZ treatment schedule is attributed mainly to non-medical reasons.
Url:
DOI: 10.31138/mjr.30.3.177
PubMed: 32185362
PubMed Central: 7045860
Affiliations:
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Markatseli</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Theodoridou, Athina" sort="Theodoridou, Athina" uniqKey="Theodoridou A" first="Athina" last="Theodoridou">Athina Theodoridou</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Academic Clinical Fellow, Rheumatology Unit, D’ Internal Medicine Department, Hippokrateion University Hospital, Thessaloniki, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Academic Clinical Fellow, Rheumatology Unit, D’ Internal Medicine Department, Hippokrateion University Hospital, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Zakalka, Marina" sort="Zakalka, Marina" uniqKey="Zakalka M" first="Marina" last="Zakalka">Marina Zakalka</name><affiliation><nlm:aff id="AFF3">Research Fellow, Division of Clinical Immunology, 1<sup>st</sup> Internal Medicine Department, AHEPA University Hospital, Thessaloniki Greece,</nlm:aff><wicri:noCountry code="subfield">Thessaloniki Greece</wicri:noCountry></affiliation></author><author><name sortKey="Koukli, Eftychia" sort="Koukli, Eftychia" uniqKey="Koukli E" first="Eftychia" last="Koukli">Eftychia Koukli</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Triantafyllidou, Eva" sort="Triantafyllidou, Eva" uniqKey="Triantafyllidou E" first="Eva" last="Triantafyllidou">Eva Triantafyllidou</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Academic Clinical Fellow, Rheumatology Unit, D’ Internal Medicine Department, Hippokrateion University Hospital, Thessaloniki, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Academic Clinical Fellow, Rheumatology Unit, D’ Internal Medicine Department, Hippokrateion University Hospital, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Tsalavos, Sotiris" sort="Tsalavos, Sotiris" uniqKey="Tsalavos S" first="Sotiris" last="Tsalavos">Sotiris Tsalavos</name><affiliation wicri:level="1"><nlm:aff id="AFF5">Roche Hellas, Marousi, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Roche Hellas, Marousi</wicri:regionArea><wicri:noRegion>Marousi</wicri:noRegion></affiliation></author><author><name sortKey="Andrianakos, Alexandros" sort="Andrianakos, Alexandros" uniqKey="Andrianakos A" first="Alexandros" last="Andrianakos">Alexandros Andrianakos</name><affiliation wicri:level="3"><nlm:aff id="AFF6">Iaso General Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Iaso General Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Drosos, Alexandros A" sort="Drosos, Alexandros A" uniqKey="Drosos A" first="Alexandros A." last="Drosos">Alexandros A. 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Results from the Single Arm REMISSION II Study (NCT01649817)</title><author><name sortKey="Markatseli, Theodora E" sort="Markatseli, Theodora E" uniqKey="Markatseli T" first="Theodora E." last="Markatseli">Theodora E. Markatseli</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author><author><name sortKey="Theodoridou, Athina" sort="Theodoridou, Athina" uniqKey="Theodoridou A" first="Athina" last="Theodoridou">Athina Theodoridou</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Academic Clinical Fellow, Rheumatology Unit, D’ Internal Medicine Department, Hippokrateion University Hospital, Thessaloniki, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Academic Clinical Fellow, Rheumatology Unit, D’ Internal Medicine Department, Hippokrateion University Hospital, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Zakalka, Marina" sort="Zakalka, Marina" uniqKey="Zakalka M" first="Marina" last="Zakalka">Marina Zakalka</name><affiliation><nlm:aff id="AFF3">Research Fellow, Division of Clinical Immunology, 1<sup>st</sup> Internal Medicine Department, AHEPA University Hospital, Thessaloniki Greece,</nlm:aff><wicri:noCountry code="subfield">Thessaloniki Greece</wicri:noCountry></affiliation></author><author><name sortKey="Koukli, Eftychia" sort="Koukli, Eftychia" uniqKey="Koukli E" first="Eftychia" last="Koukli">Eftychia Koukli</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Private Practice, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Private Practice</wicri:regionArea></affiliation></author><author><name sortKey="Triantafyllidou, Eva" sort="Triantafyllidou, Eva" uniqKey="Triantafyllidou E" first="Eva" last="Triantafyllidou">Eva Triantafyllidou</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Academic Clinical Fellow, Rheumatology Unit, D’ Internal Medicine Department, Hippokrateion University Hospital, Thessaloniki, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Academic Clinical Fellow, Rheumatology Unit, D’ Internal Medicine Department, Hippokrateion University Hospital, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Tsalavos, Sotiris" sort="Tsalavos, Sotiris" uniqKey="Tsalavos S" first="Sotiris" last="Tsalavos">Sotiris Tsalavos</name><affiliation wicri:level="1"><nlm:aff id="AFF5">Roche Hellas, Marousi, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Roche Hellas, Marousi</wicri:regionArea><wicri:noRegion>Marousi</wicri:noRegion></affiliation></author><author><name sortKey="Andrianakos, Alexandros" sort="Andrianakos, Alexandros" uniqKey="Andrianakos A" first="Alexandros" last="Andrianakos">Alexandros Andrianakos</name><affiliation wicri:level="3"><nlm:aff id="AFF6">Iaso General Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Iaso General Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Drosos, Alexandros A" sort="Drosos, Alexandros A" uniqKey="Drosos A" first="Alexandros A." last="Drosos">Alexandros A. Drosos</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece,</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation></author></analytic><series><title level="j">Mediterranean Journal of Rheumatology</title><idno type="eISSN">2529-198X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective/Aim:</title><p>One of the most important factors that affect a treatment’s performance in rheumatoid arthritis (RA) is adherence to medications. According to literature, there are several reasons for non-adherence in RA patients with some of them being related to a specific patient profile of the study population. In this study, we investigated persistence to intravenous tocilizumab (TCZ) therapy in RA during routine clinical practice in Greece and identified causes for non-adherence.</p></sec><sec><title>Methods:</title><p>183 RA patients who mostly attended private practice Rheumatologists and received intravenous TCZ treatment at a schedule of 1 infusion per 4-weeks in the first 6 months were recorded retrospectively.</p></sec><sec><title>Results:</title><p>Persistence estimated rate to TCZ therapy was 92.0% for patients that received 6 infusions and 83.4% for patients that received 7 infusions of TCZ. Potential factors that influence persistence to therapy were the occurrence of adverse events and response to the therapy. The main reasons for non-adherence to TCZ therapy were non-medically related with the most common being drug supply issues. The 6-month mean change from baseline in DAS28-ESR after initiation of TCZ therapy was −1.3, and the mean CDAI dropped from 29.6 at baseline to 16.7 at 6 months. Good/Moderate response was achieved by 89.1% of patients and remission by 23.5%. The safety profile was similar to that observed in other TCZ trials with the most common being infections, hematologic manifestations and musculoskeletal disorders.</p></sec><sec><title>Conclusion:</title><p>Overall, persistence to therapy appeared to be high in the rheumatology private practice setting and non-adherence to the TCZ treatment schedule is attributed mainly to non-medical reasons.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alamanos, Y" uniqKey="Alamanos Y">Y Alamanos</name></author><author><name sortKey="Drosos, Aa" uniqKey="Drosos A">AA Drosos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Breedveld, Fc" uniqKey="Breedveld F">FC Breedveld</name></author><author><name sortKey="Burmester, Gr" uniqKey="Burmester G">GR Burmester</name></author><author><name sortKey="Bykerk, V" uniqKey="Bykerk 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sortKey="Khilfeh, I" uniqKey="Khilfeh I">I Khilfeh</name></author><author><name sortKey="Guyette, E" uniqKey="Guyette E">E Guyette</name></author><author><name sortKey="Watkins, J" uniqKey="Watkins J">J Watkins</name></author><author><name sortKey="Danielson, D" uniqKey="Danielson D">D Danielson</name></author><author><name sortKey="Gross, D" uniqKey="Gross D">D Gross</name></author><author><name sortKey="Yeung, K" uniqKey="Yeung K">K Yeung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Souliotis, K" uniqKey="Souliotis K">K Souliotis</name></author><author><name sortKey="Papageorgiou, M" uniqKey="Papageorgiou M">M Papageorgiou</name></author><author><name sortKey="Politi, A" uniqKey="Politi A">A Politi</name></author><author><name sortKey="Ioakeimidis, D" uniqKey="Ioakeimidis D">D Ioakeimidis</name></author><author><name sortKey="Sidiropoulos, P" uniqKey="Sidiropoulos P">P Sidiropoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinblatt, Me" uniqKey="Weinblatt M">ME Weinblatt</name></author><author><name sortKey="Kremer, J" uniqKey="Kremer J">J Kremer</name></author><author><name sortKey="Cush, J" uniqKey="Cush J">J Cush</name></author><author><name sortKey="Rigby, W" uniqKey="Rigby W">W Rigby</name></author><author><name sortKey="Teng, Ll" uniqKey="Teng L">LL Teng</name></author><author><name sortKey="Devenport, J" uniqKey="Devenport J">J Devenport</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Grèce</li></country><region><li>Attique (région)</li></region><settlement><li>Athènes</li></settlement></list><tree><noCountry><name sortKey="Zakalka, Marina" sort="Zakalka, Marina" uniqKey="Zakalka M" first="Marina" last="Zakalka">Marina Zakalka</name></noCountry><country name="Grèce"><noRegion><name sortKey="Markatseli, Theodora E" sort="Markatseli, Theodora E" uniqKey="Markatseli T" first="Theodora E." last="Markatseli">Theodora E. Markatseli</name></noRegion><name sortKey="Andrianakos, Alexandros" sort="Andrianakos, Alexandros" uniqKey="Andrianakos A" first="Alexandros" last="Andrianakos">Alexandros Andrianakos</name><name sortKey="Drosos, Alexandros A" sort="Drosos, Alexandros A" uniqKey="Drosos A" first="Alexandros A." last="Drosos">Alexandros A. Drosos</name><name sortKey="Koukli, Eftychia" sort="Koukli, Eftychia" uniqKey="Koukli E" first="Eftychia" last="Koukli">Eftychia Koukli</name><name sortKey="Theodoridou, Athina" sort="Theodoridou, Athina" uniqKey="Theodoridou A" first="Athina" last="Theodoridou">Athina Theodoridou</name><name sortKey="Triantafyllidou, Eva" sort="Triantafyllidou, Eva" uniqKey="Triantafyllidou E" first="Eva" last="Triantafyllidou">Eva Triantafyllidou</name><name sortKey="Tsalavos, Sotiris" sort="Tsalavos, Sotiris" uniqKey="Tsalavos S" first="Sotiris" last="Tsalavos">Sotiris Tsalavos</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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